Greeneville is a town in, and the county seat of Greene County, Tennessee, United States. The population as of the 2010 census was 15,062. The town was named in honor of Revolutionary War hero Nathanael Greene. It is the only town with this spelling in the United States, although there are numerous U.S. towns named Greenville. The town was the capital of the short-lived State of Franklin in the 18th-century history of the Tennessee region.
Greeneville is notable as the town where President Andrew Johnson began his political career when elected from his trade as a tailor. He and his family lived there most of his adult years. It was an area of strong abolitionist and Unionist views and yeoman farmers, an environment which influenced Johnson's outlook.
The Greeneville Historic District was established in 1974.
The U.S. Navy Los Angeles-class submarine USS Greeneville (SSN-772) was named in honor of the town.
The town officially hosts the Greeneville Astros baseball club of the Appalachian League, though the club actually plays in the nearby city of Tusculum.
Greeneville is part of the Johnson City-Kingsport- Bristol TN-VA Combined Statistical Area – commonly known as the "Tri-Cities" region.