Hartsville is the largest city in Darlington County, South Carolina, United States. The population was 7,764 at the 2010 census. Mel Pennington is the current mayor. Hartsville has been an All-America City since 1996 and a National Arbor Day Foundation Tree City since 1986.
Hartsville is the home of Coker College and a branch of Florence–Darlington Technical College. It is also the site of the South Carolina Governor's School for Science and Mathematics, a public boarding high school.
The city is served by the Hartsville Regional Airport.
Hartsville is home to several major corporations including Sonoco Products Company and Duke Energy Progress. Agrium Inc. maintained a Rainbow Fertilizer plant in Hartsville until it was destroyed by fire on February 14, 2011. Agrium has chosen not to rebuild in Hartsville.