St. Joseph (informally St. Joe) is a city in and the county seat of Buchanan County, Missouri, United States. It is the principal city of the St. Joseph Metropolitan Statistical Area, which includes Buchanan, Andrew, and DeKalb counties in Missouri and Doniphan County, Kansas. As of the 2010 census, St. Joseph had a total population of 76,780, making it the eighth largest city in the state, third largest in Northwest Missouri. The metropolitan area had a population of 127,329 in 2010.
St. Joseph is located on the Missouri River, but is perhaps best known as the starting point of the Pony Express and the death place of Jesse James. St. Joseph is also home to Missouri Western State University.